Newton was a preemie

Sir Isaac Newton surrounded by symbols of some of his greatest findings.

Born two to three months prematurely on January 4, 1643, in a hamlet in Lincolnshire, England, Isaac Newton was a tiny baby who, according to his mother, could have fit inside a quart mug. A practical child, he enjoyed constructing models, including a tiny mill that actually ground flour—powered by a mouse running in a wheel.
Admitted to the University of Cambridge on 1661, Newton at first failed to shine as a student.
In 1665 the school temporarily closed because of a bubonic plague epidemic and Newton returned home to Lincolnshire for two years. It was then that the apple-falling brainstorm occurred, and he described his years on hiatus as "the prime of my age for invention."
Despite his apparent affinity for private study, Newton returned to Cambridge in 1667 and served as a mathematics professor and in other capacities until 1696.